{"id":1721,"date":"2020-12-09T18:15:48","date_gmt":"2020-12-09T22:15:48","guid":{"rendered":"https:\/\/www.nutriiq.ca\/wordpress\/?p=1721"},"modified":"2024-07-26T22:01:28","modified_gmt":"2024-07-27T02:01:28","slug":"histamine-intolerance-and-allergic-reactions-in-mental-disease","status":"publish","type":"post","link":"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/","title":{"rendered":"Histamine Intolerance: Am I Crazy or Allergic?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">On this page<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69e340915e0e5\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69e340915e0e5\" checked aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Histamine_Role\" >Histamine Role<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#What_is_Histamine_Intolerance\" >What is Histamine Intolerance?<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Identification_of_Histamine_Intolerance\" >Identification of Histamine Intolerance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Histamine_Sources_and_Degradation\" >Histamine Sources and Degradation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Blending_into_the_Crowd\" >Blending into the Crowd<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Allergy_Food_Sensitivity_and_Histamine_Intolerance\" >Allergy, Food Sensitivity, and Histamine Intolerance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Histamine_Role_for_Nervous_System\" >Histamine Role for Nervous System<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Histamine_Intolerance_and_GI_Tract\" >Histamine Intolerance and GI Tract<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Addressing_Histamine_Intolerance\" >Addressing Histamine Intolerance<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Addressing_Stress_Levels\" >Addressing Stress Levels<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Histamine-Friendly_Nutrition\" >Histamine-Friendly Nutrition<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Reducing_Histamine_Load\" >Reducing Histamine Load<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Improving_Histamine_Metabolism\" >Improving Histamine Metabolism<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Reduction_of_Exogenous_Histamine\" >Reduction of Exogenous Histamine<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Addressing_Histamine_Intolerance_with_Medications\" >Addressing Histamine Intolerance with Medications<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Pharmacological_Antihistamines\" >Pharmacological Antihistamines<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Nutraceutical_Antihistamines\" >Nutraceutical Antihistamines<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Nutraceuticals_for_Histamine_Degradation\" >Nutraceuticals for Histamine Degradation<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/nav><\/div>\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Nutri-IQ recommends to Wellness Practitioners the <a href=\"https:\/\/www.nutriiq.ca\/histamine.html\" target=\"_blank\" rel=\"noreferrer noopener\">Histamine Intolerance Assessment Tool<\/a> to check histamine intolerance as a possible cause of client&#8217;s complains. This article provides a snapshot of the evidence-based ways to recognize and manage histamine intolerance, and addresses its links to mental and gastrointestinal diseases.<\/p>\n\n\n\n<p><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-white-color\">Take\u00a0<strong><a href=\"https:\/\/www.nutriiq.ca\" target=\"_blank\" rel=\"noreferrer noopener\">a minute <\/a><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/contact-us\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">to review<\/a>\u00a0<\/strong>and find your vitamins deficiencies &#8211; they may be a root cause of your symptoms and intolerances!<\/mark><\/p>\n<\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<pre class=\"wp-block-verse\" id=\"HI-prevalence\">Whatever the reason is, the world is undergoing an epidemic of allergy and mysterious intolerances. In the western world, adverse reactions to ingested foods affect up to 20% of the population<span id='easy-footnote-1-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-1-1721' title='Schnedl WJ, Enko D. Considering histamine in functional gastrointestinal disorders. Crit Rev Food Sci Nutr. 2020 Jul 9:1-8. doi: 10.1080\/10408398.2020.1791049.'><sup>1<\/sup><\/a><\/span> - cumulatively, this number is equal to the whole USA population<span id='easy-footnote-2-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-2-1721' title='&lt;a href=&quot;https:\/\/worldpopulationreview.com\/country-rankings\/western-countries&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;Western Countries 2020&lt;\/a&gt;. Downloaded on January 6, 2021'><sup>2<\/sup><\/a><\/span>.\n\nSpread of mental illness is catastrophic - nearly 50% of the USA adults will develop at least one mental illness during their lifetime<span id='easy-footnote-3-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-3-1721' title='Tucci, V., &amp;amp; Moukaddam, N. (2017). We are the hollow men: The worldwide epidemic of mental illness, psychiatric and behavioral emergencies, and its impact on patients and providers. &lt;em&gt;Journal of emergencies, trauma, and shock,&lt;\/em&gt; 10(1), 4\u20136. https:\/\/doi.org\/10.4103\/0974-2700.199517'><sup>3<\/sup><\/a><\/span>.  Inability to properly digest food is frightening: more than 40% of persons worldwide have functional gastrointestinal disorders, by the study of 33 countries on 6 continents<span id='easy-footnote-4-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-4-1721' title='AD. Sperber, SI Bangdiwala, DA Drossman, UC Ghoshal, M Simren, J Tack, WE Whitehead, DL Dumitrascu, X Fang, S Fukudo, J Kellow, E Okeke, EMM Quigley, M Schmulson, P Whorwell, T Archampong, P Adibi, V Andresen, MA Benninga, B Bonaz, S Bor, LB Fernandez, SC Choi, ES Corazziari, C Francisconi, A Hani, L Lazebnik, YY Lee, A Mulak, MM Rahman, J Santos, M Setshedi, AF Syam, S Vanner, RK Wong, A Lopez-Colombo, V Costa, R Dickman, M Kanazawa, AH Keshteli, R Khatun, I Maleki, P Poitras, N Pratap, O Stefanyuk, S Thomson, J Zeevenhooven, OS Palsson, Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study, &lt;em&gt;Gastroenterology&lt;\/em&gt;, Volume 160, Issue 1, 2021, Pages 99-114.e3,ISSN 0016-5085, https:\/\/doi.org\/10.1053\/j.gastro.2020.04.014.'><sup>4<\/sup><\/a><\/span>. \n\n\nAnd there is a hypothesis about an almost universal root cause for this avalanche of mysterious diseases: <strong>histamine intolerance<\/strong>. In this article, we will consider adverse systemic effects of excess histamine and its insufficient degradation, that is, histamine intolerance. We also will explain the role histamine plays in the body, and analyze its impact as physiological functions modulator. We also provide extensive bibliography of research and review scientific work covering these topics.<\/pre>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamine_Role\"><\/span>Histamine Role<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Histamine is a small organic molecule that plays an important role in the body. It is known to be involved in 23 different physiological functions<span id='easy-footnote-5-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-5-1721' title='Wikipedia. Downloaded on December 14, 2020'><sup>5<\/sup><\/a><\/span>. Among histamine physiological roles are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>immune response to foreign pathogens,<\/li>\n\n\n\n<li>increase the permeability of the capillaries to white blood cells and some proteins, to allow them to affect pathogens in the infected tissues,<\/li>\n\n\n\n<li>local immune responses, <\/li>\n\n\n\n<li>inflammatory response,<\/li>\n\n\n\n<li>mediation of itching,<\/li>\n\n\n\n<li>regulation of digestion,<\/li>\n\n\n\n<li>vasodilation and blood pressure regulation,<\/li>\n\n\n\n<li>serving as a neurotransmitter for the brain, spinal cord, and uterus.<\/li>\n<\/ul>\n\n\n\n<p>Histamine realizes its physiological functions via 4 receptors<span id='easy-footnote-6-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-6-1721' title='Shirley, David W. PharmD; Sterrett, James PharmD, CDE; Haga, Neal PharmD; Durham, Catherine DNP, FNP&amp;nbsp;The therapeutic versatility of antihistamines, &lt;em&gt;The Nurse Practitioner:&lt;\/em&gt; February 2020 &amp;#8211; Volume 45 &amp;#8211; Issue 2 &amp;#8211; p 8-21 doi: 10.1097\/01.NPR.0000651112.76528.ed'><sup>6<\/sup><\/a><\/span>. The receptors are extensively distributed within the body.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\" id=\"receptor-function\"><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2020\/12\/image-1.png\"><img decoding=\"async\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2020\/12\/image-1.png\" alt=\"\" class=\"wp-image-1746\"\/><\/a><figcaption class=\"wp-element-caption\">Histamine receptors: The Nurse Practitioner45(2):8-21, February 2020.<\/figcaption><\/figure>\n\n\n\n<p>Due to the diversity of its physiological functions, histamine can be both a friend and a universal culprit with systemic effects. <\/p>\n\n\n\n<p>Some health problems, such as high blood pressure, easily resolved by injecting extra histamine<span id='easy-footnote-7-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-7-1721' title='Potnuri, A.G., Allakonda, L., Appavoo, A.&amp;nbsp;&lt;em&gt;et al.&lt;\/em&gt;&amp;nbsp;Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol.&lt;em&gt;Hypertens Res&lt;\/em&gt;&amp;nbsp;&lt;strong&gt;41,&amp;nbsp;&lt;\/strong&gt;1023\u20131035 (2018). https:\/\/doi.org\/10.1038\/s41440-018-0109-2'><sup>7<\/sup><\/a><\/span>. Histamine\u2019s actions are great for protecting the body against parasites<span id='easy-footnote-8-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-8-1721' title='The Human Body. Editor(s): Bruce M. Carlson, Academic Press, 2019, ISBN 9780128042540, https:\/\/doi.org\/10.1016\/B978-0-12-804254-0.00008-9'><sup>8<\/sup><\/a><\/span>. But it also can be a ruthless killer. It is a common knowledge now that sudden histamine release resulting from COVID-19 cytokine storm can kill the host <span id='easy-footnote-9-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-9-1721' title='J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5):1629-1632. doi: 10.23812\/20-2EDIT.'><sup>9<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Our primary focus in this article is harmful effects of excess histamine in the body, that is, histamine intolerance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_is_Histamine_Intolerance\"><\/span>What is Histamine Intolerance?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p id=\"histamine-balancing\">According to <span id='easy-footnote-10-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-10-1721' title='Comas-Bast\u00e9, O.; S\u00e1nchez-P\u00e9rez, S.; Veciana-Nogu\u00e9s, M.T.; Latorre-Moratalla, M.; Vidal-Carou, M.d.C. Histamine Intolerance: The Current State of the Art. &lt;em&gt;Biomolecules&lt;\/em&gt; 2020, 10, 1181.'><sup>10<\/sup><\/a><\/span> &#8220;histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century&#8221;. <\/p>\n\n\n\n<p>Histamine intolerance is an indication that too much histamine is circulating in the body<span id='easy-footnote-11-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-11-1721' title='&lt;a href=&quot;https:\/\/www.entandallergy.com\/blog-posts\/details\/your-mystery-food-sensitivity-might-actually-be-a-histamine-intolerance&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;What is histamine intolerance?&lt;\/a&gt; Downloaded on Dec. 16, 2020'><sup>11<\/sup><\/a><\/span>. Histamine intolerance results from an excess of accumulated histamine and a lower capacity for histamine degradation. Obviously, the more unneeded histamine is imbalanced in the body, the more <a href=\"#histamine-intolerance-symptoms\">severe symptoms<\/a> caused by the excess histamine may occur.<\/p>\n\n\n\n<p id=\"histamine-metabolism\">Most histamine in the body is preformed, stored in granules in mast cells and in basophils, released as needed, and then metabolized.<\/p>\n\n\n\n<p>Excess of mast cell-derived histamine in circulation plays an important role in conditions associated with vascular leakage like urticaria and anaphylaxis, and is involved in other disorders, i.e. atopic dermatitis, asthma, and rheumatoid arthritis<span id='easy-footnote-12-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-12-1721' title='Lieberman P, Garvey LH (2016) Mast cells and anaphylaxis. &lt;em&gt;Curr Allergy Asthma Rep&lt;\/em&gt;16:20'><sup>12<\/sup><\/a><\/span>. In food allergies, it can cause vomiting and diarrhea.<\/p>\n\n\n\n<p>Please note that despite the substantial evidence accumulated about histamine metabolism, receptors, signal transmission, and physiological and pathological effects, the complex interrelationships involving histamine yet remain to be understood<span id='easy-footnote-13-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-13-1721' title='Jutel M, Blaser K, Akdis CA. The role of histamine in regulation of immune responses. &lt;em&gt;Chem Immunol Allergy.&lt;\/em&gt; 2006;91:174-87. doi: 10.1159\/000090280. PMID: 16354958.'><sup>13<\/sup><\/a><\/span>. And since this is an emerging topic, intolerance\u2010related physiological symptoms are not reliably treatable &#8211; yet.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Identification_of_Histamine_Intolerance\"><\/span>Identification of Histamine Intolerance<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Diagnosis of histamine intolerance is difficult as clinical symptoms are often attributed to different diseases, such as allergy and food intolerance, or even mental disease. To commence differential diagnostics and assess the probability of histamine intolerance as a possible root cause, several questionnaires analyze a given set of the symptoms<span id='easy-footnote-14-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-14-1721' title='Schnedl, W. J., Lackner, S., Enko, D., Schenk, M., Holasek, S. J., &amp;amp; Mangge, H. (2019). Evaluation of symptoms and symptom combinations in histamine intolerance. &lt;em&gt;Intestinal research,&lt;\/em&gt; 17(3), 427\u2013433. https:\/\/doi.org\/10.5217\/ir.2018.00152'><sup>14<\/sup><\/a><\/span>. Poly-intolerances\/sensitivities are the most likely to be related to histamine intolerance<span id='easy-footnote-15-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-15-1721' title='Litschauer-Poursadrollah M, El-Sayad S, Wantke F, Fellinger C, Jarisch R. Bauchschmerzen, Bl\u00e4hbauch, Diarrhoe: Fruktosemalabsorption, Laktoseintoleranz oder Reizdarmsyndrom? [Abdominal spasms, meteorism, diarrhea: fructose intolerance, lactose intolerance or IBS?]. &lt;em&gt;Wien Med Wochenschr.&lt;\/em&gt; 2012 Dec;162(23-24):506-12. German. doi: 10.1007\/s10354-012-0158-0.&amp;nbsp;'><sup>15<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Nutri-IQ is offering to its subscribers the convenient form of the <a href=\"https:\/\/www.nutriiq.ca\/histamine.html\" target=\"_blank\" rel=\"noreferrer noopener\">questionnaire proposed and confirmed by Beverley Rider<span id='easy-footnote-16-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-16-1721' title='Beverley Rider. \u201cHives, Headaches and Heartburn: Heal Your Histamine Hangover\u201d. Summerland Publishing, 2020, ISBN-10: 1732907226'><sup>16<\/sup><\/a><\/span>. We have to note that the <\/a>evaluation of histamine intolerance assessment questionnaires is a popular research topic<span id='easy-footnote-17-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-17-1721' title='Evaluation of symptoms and symptom combinations in histamine intolerance. Intest Res. 2019;17(3):427-433. Published online March 7, 2019, DOI: https:\/\/doi.org\/10.5217\/ir.2018.00152 '><sup>17<\/sup><\/a><\/span>! If histamine intolerance is likely, a histamine ELISA (blood plasma histamine level) test can be ordered for the client. Blood allergy tests or skin testing will not be positive since histamine intolerance is not mediated by IgE antibodies.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamine_Sources_and_Degradation\"><\/span>Histamine Sources and Degradation<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>There are endogenous (internal) and exogenous (external) sources of histamine that can lead to histamine intolerance<span id='easy-footnote-18-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-18-1721' title='Kovacova-Hanuskova E, et al. Histamine, histamine intoxication and intolerance. &lt;em&gt;Allergol Immunopathol (Madr)&lt;\/em&gt;. 2015.&amp;nbsp;http:\/\/dx.doi.org\/10.1016\/j.aller.2015.05.001'><sup>18<\/sup><\/a><\/span>. The article points out the following sources of histamine:<\/p>\n\n\n\n<p><strong>Endogenous sources of histamine:<\/strong><\/p>\n\n\n\n<ul id=\"histamine-sources\" class=\"wp-block-list\">\n<li>gastric enterochromaffin cells, <\/li>\n\n\n\n<li>histaminergic neurons, <\/li>\n\n\n\n<li>mast cells and basophils which store histamine in intracellular vesicles release histamine upon stimulation by non-immune, chemical, and physical factors:\n<ul class=\"wp-block-list\">\n<li>neuropeptides (substance P), <\/li>\n\n\n\n<li>parts of complement system, <\/li>\n\n\n\n<li>immunity and inflammation mediators cytokines (IL-1, IL-3, IL-8, and GM-CSF), <\/li>\n\n\n\n<li>platelet activating factor (PAF), <\/li>\n\n\n\n<li>hyperosmolarity (high concentration sodium or glucose in the blood), <\/li>\n\n\n\n<li>lipoproteins (cholesterol), <\/li>\n\n\n\n<li>adenosine and some other medications, <\/li>\n\n\n\n<li>enzymes, i.e. superoxidases,<\/li>\n\n\n\n<li>hypoxia,<\/li>\n\n\n\n<li>extreme temperatures, <\/li>\n\n\n\n<li>stress and trauma via corticotropin-releasing factor sending signals to mast cells to release histamine<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Exogenous sources of histamine:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ingestion of high-histamine foods (due to thermostability, histamine which is present in food is almost irremovable), i.e. fermented foods, beer, wine, cheeses, meat, soy, yogurt, <\/li>\n\n\n\n<li>microbial decarboxylation of histidine by different fermenting bacteria, including natural human flora in the gut.<\/li>\n<\/ul>\n\n\n\n<p id=\"histamine-metabolism\"><strong>Histamine degradation:<\/strong><\/p>\n\n\n\n<p id=\"histamine-metabolism\">Histamine is metabolized extracellularly by diamine oxidase (DAO), or intracellularly by histamine-N-methyltransferase (HNMT)<span id='easy-footnote-19-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-19-1721' title='Laura Maintz, Natalija Novak, Histamine and histamine intolerance, &lt;em&gt;The American Journal of Clinical Nutrition,&lt;\/em&gt; Volume 85, Issue 5, May 2007, Pages 1185\u20131196, https:\/\/doi.org\/10.1093\/ajcn\/85.5.1185'><sup>19<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Please note that for proper functioning of DAO enzyme, it needs cofactors: vitamins B6 and C, and copper<span id='easy-footnote-20-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-20-1721' title='Comas-Bast\u00e9, Oriol &amp;amp; Latorre-Moratalla, Maria&amp;nbsp;Luz &amp;amp; S\u00e1nchez-P\u00e9rez, S\u00f2nia &amp;amp; Veciana-Nogu\u00e9s, M. Teresa &amp;amp; Vidal-Carou, M. Carmen. (2019). Histamine and Other Biogenic Amines in Food.&lt;em&gt; From Scombroid Poisoning to Histamine Intolerance. &lt;\/em&gt;10.5772\/intechopen.84333.'><sup>20<\/sup><\/a><\/span>.&nbsp;Nutrition competency regarding these cofactors can be checked using Nutri-IQ<a href=\"https:\/\/www.nutriiq.ca\/nutriIQ.php\" target=\"_blank\" rel=\"noreferrer noopener\"> Nutritional Balance Assessment Tool<\/a>. DAO can be inhibited by some medications, such as chloroquine, clavulanic acid, Cimetidine, verapamil, isoniazid, metamizole, acetyl cysteine, amitriptyline, diclofenac, metoclopramide, suxamethonium, thiamine (vitamin B1)<span id='easy-footnote-21-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-21-1721' title='Leitner, R., Zoernpfenning, E., &amp;amp; Missbichler, A. (2014). Evaluation of the inhibitory effect of various drugs \/ active ingredients on the activity of human diamine oxidase&amp;nbsp;&lt;em&gt;in vitro&lt;\/em&gt;.&amp;nbsp;&lt;em&gt;Clinical and Translational Allergy&lt;\/em&gt;,&amp;nbsp;&lt;em&gt;4&lt;\/em&gt;(Suppl 3), P23. https:\/\/doi.org\/10.1186\/2045-7022-4-S3-P23'><sup>21<\/sup><\/a><\/span>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Blending_into_the_Crowd\"><\/span>Blending into the Crowd<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Further in this article, we will consider how histamine intolerance blends with other health issues. Keep in mind that addressing the root cause, histamine intolerance, will almost instantly alleviate related issues!<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-1.png\"><img loading=\"lazy\" decoding=\"async\" width=\"729\" height=\"473\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-1.png\" alt=\"\" class=\"wp-image-1849\" style=\"width:649px;height:421px\" srcset=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-1.png 729w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-1-300x195.png 300w\" sizes=\"auto, (max-width: 729px) 100vw, 729px\" \/><\/a><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergy_Food_Sensitivity_and_Histamine_Intolerance\"><\/span>Allergy, Food Sensitivity, and Histamine Intolerance<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>In allergies and food sensitivities, the immune system overreacts to harmless substances instead of invaders.  It is easy to distinguish &#8220;classic&#8221; allergy from food sensitivity by the mediation type (IgG vs IgE antibodies <span id='easy-footnote-22-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-22-1721' title='Food Allergy and Food Intolerance. Downloaded from on Dec. 23, 2020'><sup>22<\/sup><\/a><\/span> ), and the fact that sensitivities do not cause anaphylactic shock reaction. The number of people affected by these problems is equal to the <a href=\"#HI-prevalence\">whole USA population<\/a>!<\/p>\n\n\n\n<p>The clinical expression of allergic diseases depends on the actions of several mediators. Histamine, as it was recognized and studied since 1911, is prominent among them<span id='easy-footnote-23-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-23-1721' title='MV White, The role of histamine in allergic diseases, &lt;em&gt;Journal of Allergy and Clinical Immunology,&lt;\/em&gt; Volume 86, Issue 4, Part 2, 1990, Pages 599-605, ISSN 0091-6749, https:\/\/doi.org\/10.1016\/S0091-6749(05)80223-4'><sup>23<\/sup><\/a><\/span>. Histamine mediates the following symptoms in anaphylaxis and allergic responses of the skin, nose, and airways:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>bronchospasm, edema , and mucus secretion in asthma,  <\/li>\n\n\n\n<li>pruritus, mucosal edema and secretion, sneezing in allergic rhinitis, <\/li>\n\n\n\n<li>urticaria (vasodilation, vascular permeability, and pruritus) in the skin reactions,  <\/li>\n\n\n\n<li>vascular permeability, smooth muscle contraction, mucus secretion and tachycardia in anaphylaxis.<\/li>\n<\/ul>\n\n\n\n<p>Excess histamine may exacerbate the above symptoms as an uncontrolled process mediator. Thus, it becomes the foe.<\/p>\n\n\n\n<p>If histamine intolerance is suspected, lab tests of the histamine plasma levels can be performed. Levels above &gt;10 nmol\/L correlate with severe allergic response<span id='easy-footnote-24-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-24-1721' title='Lin RY, Schwartz LB, Curry A, Pesola GR, Knight RJ, Lee HS, Bakalchuk L, Tenenbaum C, Westfal RE. Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study. &lt;em&gt;J Allergy Clin Immunol.&lt;\/em&gt; 2000 Jul;106(1 Pt 1):65-71. doi: 10.1067\/mai.2000.107600.'><sup>24<\/sup><\/a><\/span>. Plasma histamine levels of the subjects with suspected histamine intolerance is usually higher that for those with food allergy<span id='easy-footnote-25-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-25-1721' title='Pinzer, TC,&amp;nbsp;&amp;nbsp;Tietz, E,&amp;nbsp;&amp;nbsp;Waldmann, E,&amp;nbsp;&amp;nbsp;Schink, M,&amp;nbsp;&amp;nbsp;Neurath, MF,&amp;nbsp;&amp;nbsp;Zopf, Y.&amp;nbsp;&amp;nbsp;Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls.&amp;nbsp;&lt;em&gt;Allergy&lt;\/em&gt;.&amp;nbsp;&amp;nbsp;2018;&amp;nbsp;73:&amp;nbsp;949\u2010&amp;nbsp;957.&amp;nbsp;&lt;a href=&quot;https:\/\/doi.org\/10.1111\/all.13361&quot;&gt;https:\/\/doi.org\/10.1111\/all.13361&lt;\/a&gt;'><sup>25<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>The most typical among the histamine intolerance symptoms are<span id='easy-footnote-26-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-26-1721' title='W\u00f6hrl, Stefan; Hemmer, Wolfgang; Focke, Margarete; Rappersberger, Klemens; Reinhart Jarisch. Histamine Intolerance-Like Symptoms in Healthy Volunteers after Oral Provocation with Liquid Histamine.  &lt;em&gt;Allergy and Asthma Proc&lt;\/em&gt;; Providence Vol. 25, Iss. 5, (Sep 2004): 305-11.'><sup>26<\/sup><\/a><\/span>:<\/p>\n\n\n\n<figure id=\"histamine-intolerance-symptoms\" class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td><strong>System<\/strong><\/td><td><strong>Histamine Intolerance Symptom<\/strong><\/td><\/tr><tr><td>All systems involved<\/td><td>Body temperature rising<\/td><\/tr><tr><td>Cardio-vascular<\/td><td>Hypotension and tachycardia<\/td><\/tr><tr><td>Gastro-intestinal<\/td><td>Heartburn &#8211; due to increased acid production<br \/>Abdominal pain<br \/>Diarrhea<br \/>Vomiting<\/td><\/tr><tr><td>Respiratory<\/td><td>Anaphylaxis<br \/>Bronchial asthma<br \/>Nasal congestion, rhinorrhea, sneezing, nose and throat itching<br \/>Bronchial obstruction<\/td><\/tr><tr><td>Nervous system<\/td><td>Headaches<\/td><\/tr><tr><td>Integumentary<\/td><td>Skin pruritus (itch) <br \/>Urticaria (hives)+eczema sometimes called histamine rash<br \/>Angioedema (swelling of face\/hands\/lips)<br \/>Erythema (redness of the skin or mucous membranes caused by increased blood flow)<\/td><\/tr><tr><td>Vision<\/td><td>Ocular itch\/burning<\/td><\/tr><tr><td>Endocrine system<\/td><td>PMS &#8211; histamine-induced contractions due to hormone levels changes<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>These are very unpleasant symptoms. However &#8211; and this is good news &#8211; if histamine intolerance is suspected and confirmed, there are tools to mitigate these effects. Nutri-IQ <a href=\"https:\/\/www.nutriiq.ca\/histamine.html\" target=\"_blank\" rel=\"noreferrer noopener\">questionnaire<\/a> helps to identify the probability that systemic symptoms affecting your client in fact relate to histamine intolerance.<\/p>\n\n\n\n<p>Further, we will provide some insights on how histamine intolerance is involved with nervous and gastroenterological problems that are rarely suspected to be affected by histamine excess. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"nervous-system\"><span class=\"ez-toc-section\" id=\"Histamine_Role_for_Nervous_System\"><\/span>Histamine Role for Nervous System<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Histamine is a central nervous system neurotransmitter and neuromodulator. The histaminergic system in the human brain is really extensive (approximately 64,000 neurones)<span id='easy-footnote-27-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-27-1721' title='&lt;a href=&quot;https:\/\/mthfrsupport.com.au\/2016\/09\/how-does-histamine-effect-our-brain-and-nervous-system\/&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;How does histamine affect our brain and nervous system?&lt;\/a&gt; Downloaded on Dec. 17, 2020'><sup>27<\/sup><\/a><\/span>. <\/p>\n\n\n\n<p>Histamine is necessary to maintain wakefulness, alertness, and reaction time<span id='easy-footnote-28-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-28-1721' title='Lieberman P. Histamine, antihistamines, and the central nervous system. &lt;em&gt;Allergy Asthma Proc.&lt;\/em&gt; 2009 Sep-Oct;30(5):482-6. doi: 10.2500\/aap.2009.30.3264'><sup>28<\/sup><\/a><\/span>. Also, histamine contributes to modulation of circadian rhythms, homeostasis, motor behaviour, and cognition<span id='easy-footnote-29-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-29-1721' title='Eduardo E.&amp;nbsp;Benarroch. Histamine in the CNS. Multiple functions and potential neurologic implications. &lt;em&gt;Neurology&amp;nbsp;&lt;\/em&gt;Oct 2010,&amp;nbsp;75&amp;nbsp;(16)&amp;nbsp;1472-1479;&amp;nbsp;DOI:10.1212\/WNL.0b013e3181f884b1'><sup>29<\/sup><\/a><\/span>,<span id='easy-footnote-30-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-30-1721' title='Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. &lt;em&gt;Prog Neurobiol. &lt;\/em&gt;2001 Apr;63(6):637-72. doi: 10.1016\/s0301-0082(00)00039-3. PMID: 11164999.'><sup>30<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Evidence suggests that histamine intolerance may play an important role in the pathophysiology of some nervous system diseases, such as anxiety, depression, psychosis, stroke, Alzheimer\u2019s disease, Parkinson\u2019s disease, attention-deficit hyperactivity disorder, migraine, epilepsy, vascular dementia, mental retardation, cerebrovascular encephalopathy, multiple sclerosis, brain tumors, cranial nerve neuropathies, mental retardation and post-traumatic brain injury<span id='easy-footnote-31-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-31-1721' title='Yang, X., Liu, C., Zhang, J., Han, H., Wang, X., Liu, Z., &amp;amp; Xu, Y. (2015). Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson&amp;#8217;s disease and schizophrenia in Han Chinese: a case-control study. &lt;em&gt;PloS one, &lt;\/em&gt;10(3), e0119692. DOI:10.1371\/journal.pone.0119692'><sup>31<\/sup><\/a><\/span>, <span id='easy-footnote-32-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-32-1721' title='Cacabelos R, Torrellas C, Fern\u00e1ndez-Novoa L, Aliev G. Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection. &lt;em&gt;Curr Pharm Des. &lt;\/em&gt;2016;22(7):819-48. doi: 10.2174\/1381612822666151209150954. PMID: 26648474.'><sup>32<\/sup><\/a><\/span>. <\/p>\n\n\n\n<p><strong>Depression.<\/strong> Though it was not tested on humans, blocking histamine receptor in the brain (H3 receptor) alleviated depression-like state<span id='easy-footnote-33-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-33-1721' title='Ajeet Kumar, Shalini Dogra, Chandan Sona, Deepmala Umrao, Mamunur Rashid, Sandeep K Singh, Muhammad Wahajuddin, Prem N Yadav, Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis, &lt;em&gt;Psychoneuroendocrinology&lt;\/em&gt;, Volume 101, 2019, Pages 128-137, https:\/\/doi.org\/10.1016\/j.psyneuen.2018.11.007'><sup>33<\/sup><\/a><\/span>! <\/p>\n\n\n\n<p><strong>Insomnia.<\/strong> Short-term insomnia can be treated with antihistamines<span id='easy-footnote-34-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-34-1721' title='Joseph P. Vande Griend, Sarah L. Anderson, Histamine-1 receptor antagonism for&amp;nbsp;treatment of insomnia, &lt;em&gt;Journal of the American Pharmacists Association,&lt;\/em&gt; Volume 52, Issue 6, 2012, Pages e210-e219, ISSN 1544-3191, https:\/\/doi.org\/10.1331\/JAPhA.2012.12051'><sup>34<\/sup><\/a><\/span>. The effect is related to antagonizing H1 receptors in tuberomammillary nucleus and inhibiting the arousal pathways.<\/p>\n\n\n\n<p><strong>Epilepsy<\/strong>: A cohort study found that children with allergic rhinitis (characterized by spontaneous degranulation of mast cells and release of histamine) have a 76 % increased subsequent risk of epilepsy<span id='easy-footnote-35-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-35-1721' title='Raffaele Falsaperla, Piero Pavone, Stefano Miceli Sopo, Fahad Mahmood, Ferdinando Scalia, Giovanni Corsello, Riccardo Lubrano &amp;amp; Giovanna Vitaliti&amp;nbsp;(2014)&amp;nbsp;Epileptic seizures as a manifestation of cow\u2019s milk allergy: a studied relationship and description of our pediatric experience,&amp;nbsp;&lt;em&gt;Expert Review of Clinical Immunology&lt;\/em&gt;,&amp;nbsp;10:12,&amp;nbsp;1597-1609,&amp;nbsp;DOI:&amp;nbsp;&lt;a href=&quot;https:\/\/doi.org\/10.1586\/1744666X.2014.977259&quot;&gt;10.1586\/1744666X.2014.977259&lt;\/a&gt;'><sup>35<\/sup><\/a><\/span>. <\/p>\n\n\n\n<p><strong>Addictions:<\/strong> Review <span id='easy-footnote-36-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-36-1721' title='Torrealba, F., Riveros, M. E., Contreras, M., &amp;amp; Valdes, J. L. (2012). Histamine and motivation.&amp;nbsp;&lt;em&gt;Frontiers in systems neuroscience&lt;\/em&gt;,&amp;nbsp;&lt;em&gt;6&lt;\/em&gt;, 51. https:\/\/doi.org\/10.3389\/fnsys.2012.00051'><sup>36<\/sup><\/a><\/span> confirmed amplification effect that histamine exerts on later stages of addictive and over-consuming behaviours, when drug\/food intake is driven by habit. <\/p>\n\n\n\n<p><strong>Pain.<\/strong> Worldwide prevalence rate of neuropathic pain in the general population lies between 7% and 10% <span id='easy-footnote-37-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-37-1721' title='Obara, I, Telezhkin, V, Alrashdi, I, Chazot, PL. Histamine, histamine receptors, and neuropathic pain relief. &lt;em&gt;Br J Pharmacol.&lt;\/em&gt; 2020; 177: 580\u2013 599. https:\/\/doi.org\/10.1111\/bph.14696'><sup>37<\/sup><\/a><\/span>. Histamine is an excitatory neurotransmitter generating pain hypersensitivity. Inhibition of histamine receptor signalling causes neuroprotective and antinociceptive effects<span id='easy-footnote-38-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-38-1721' title='Popiolek-Barczyk, K., \u0141a\u017cewska, D., Latacz, G., Olejarz, A., Makuch, W., Stark, H., Kie\u0107-Kononowicz, K., &amp;amp; Mika, J. (2018). Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse. &lt;em&gt;British journal of pharmacology,&lt;\/em&gt; 175(14), 2897\u20132910. https:\/\/doi.org\/10.1111\/bph.14185'><sup>38<\/sup><\/a><\/span>. Pain\u2010modulatory effects of histamine depend on the amount of histamine administered\/circulating<span id='easy-footnote-39-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-39-1721' title='Wei, H., Viisanen, H., You, H. J., &amp;amp; Pertovaara, A. (2016). Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation\u2010induced model of experimental neuropathy. &lt;em&gt;European Journal of Pharmacology,&lt;\/em&gt; 772, 1\u201310.'><sup>39<\/sup><\/a><\/span>. The studies support the idea that H1 and H2 receptor antagonists permeable into the central nervous system may potentially be used as analgesics for patients with neuropathic pain<span id='easy-footnote-40-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-40-1721' title='Khalilzadeh, E., Azarpey, F., Hazrati, R., &amp;amp; Vafaei Saiah, G. (2018). Evaluation of different classes of histamine H1 and H2 receptor antagonist effects on neuropathic nociceptive behavior following tibial nerve transection in rats. &lt;em&gt;European Journal of Pharmacology, &lt;\/em&gt;834, 221\u2013229. https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.011'><sup>40<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Observational study of patients with severe pelvic pain due to endometriosis<span id='easy-footnote-41-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-41-1721' title='Orazov MR, Radzinskiy VY, Khamoshina MB, et al. Histamine metabolism disorder in pathogenesis of chronic pelvic pain in patients with external genital endometriosis. Patologicheskaia Fiziologiia i Eksperimental&amp;#8217;naia Terapiia. 2017 Apr-Jun;61(2):56-60.'><sup>41<\/sup><\/a><\/span> had shown statistically higher histamine intolerance levels (histamine level in peripheral blood), along with higher depression and anxiety levels.<\/p>\n\n\n\n<p><strong>Autism Spectrum Disorders (ASD): <\/strong>Another &#8220;epidemic&#8221; is proliferation of autism spectrum disorders<span id='easy-footnote-42-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-42-1721' title='Chiarotti, F., &amp;amp; Venerosi, A. (2020). Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014.&amp;nbsp;&lt;em&gt;Brain Sciences&lt;\/em&gt;,&amp;nbsp;&lt;em&gt;10&lt;\/em&gt;(5), 274. doi:10.3390\/brainsci10050274'><sup>42<\/sup><\/a><\/span>. The article estimates prevalence of ASD in western countries as high as 11 cases per 1000! According to<span id='easy-footnote-43-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-43-1721' title='Theoharis C. Theoharides, Julia M. Stewart, Smaro Panagiotidou, Isaac Melamed, Mast cells, brain inflammation and autism, &lt;em&gt;European Journal of Pharmacology,&lt;\/em&gt; Volume 778, 2016, Pages 96-102, ISSN 0014-2999, https:\/\/doi.org\/10.1016\/j.ejphar.2015.03.086.'><sup>43<\/sup><\/a><\/span>, histamine from brain mast cells may be involved in the ASD pathogenesis and can worsen symptoms with stress.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamine_Intolerance_and_GI_Tract\"><\/span>Histamine Intolerance and GI Tract<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>In the GI tract, histamine is synthesized by histidine decarboxylase (HDC) enzyme and stored in various cell types. They release histamine following activation by allergens or mitogens (peptides that induce cell division) or cytokines<span id='easy-footnote-44-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-44-1721' title='Deiteren, A., De Man, J. G., Pelckmans, P. A., &amp;amp; De Winter, B. Y. (2015). Histamine H4 receptors in the gastrointestinal tract. British journal of pharmacology, 172(5), 1165\u20131178. https:\/\/doi.org\/10.1111\/bph.12989'><sup>44<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>Functional GI disorders are characterised by chronic complaints regarding dysmotility and hypersensitivity. These complaints arise from disorganised brain\u2013gut interactions.  Functional dyspepsia and IBS (irritable bowel syndrome) are the two most prevalent FGIDs, affecting up to 16\u201326% of worldwide population<span id='easy-footnote-45-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-45-1721' title='Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. &lt;em&gt;Clin Gastroenterol Hepatol&lt;\/em&gt; 2012;10:712\u201321. doi:10.1016\/j.cgh.2012.02.029'><sup>45<\/sup><\/a><\/span>.  In turn, the study<span id='easy-footnote-46-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-46-1721' title='Wouters MM, Vicario M, Santos J (2015). &amp;#8220;The role of mast cells in functional GI disorders&amp;#8221;. Gut. 65 (1): 155\u2013168. doi:10.1136\/gutjnl-2015-309151'><sup>46<\/sup><\/a><\/span> confirmed that gut mucosa and supernatant of patients with IBS contain increased concentrations of histamine. <\/p>\n\n\n\n<p>Multiple studies confirmed successful application of antihistamine medication to alleviate IBS<span id='easy-footnote-47-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-47-1721' title='Fabisiak, A., W\u0142odarczyk, J., Fabisiak, N., Storr, M., &amp;amp; Fichna, J. (2017). Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal.&amp;nbsp;&lt;em&gt;Journal of neurogastroenterology and motility&lt;\/em&gt;,&amp;nbsp;&lt;em&gt;23&lt;\/em&gt;(3), 341\u2013348. https:\/\/doi.org\/10.5056\/jnm16203'><sup>47<\/sup><\/a><\/span>. Pain is the major inconvenience of IBS, and <a href=\"https:\/\/www.huffingtonpost.ca\/jason-tetro\/we-may-have-an-answer-for-why-ibs-pain-can-be-so-overwhelming_a_23259386\/\" target=\"_blank\" rel=\"noreferrer noopener\">histamine was confirmed as IBS pain exacerbating factor<\/a>.  <\/p>\n\n\n\n<p>In another study<span id='easy-footnote-48-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-48-1721' title='Wolfgang J. Schnedl, Harald Mangge, Michael Schenk, Dietmar Enko, Non-responsive celiac disease may coincide with additional food intolerance\/malabsorption, including histamine intolerance, &lt;em&gt;Medical Hypotheses,&lt;\/em&gt; 2020, 110404, ISSN 0306-9877, https:\/\/doi.org\/10.1016\/j.mehy.2020.110404.'><sup>48<\/sup><\/a><\/span>, histamine intolerance, that was found in more than 50% of participants with non-responsive celiac disease, was identified to play an important role in disease course.&nbsp;<\/p>\n\n\n\n<p>The most recent gastroenterology recommendation is to consider histamine intolerance in the differential diagnoses of patients with functional, nonspecific, non-allergic gastrointestinal complaints<span id='easy-footnote-49-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-49-1721' title='Schnedl WJ, Enko D. Considering histamine in functional gastrointestinal disorders. Crit Rev Food Sci Nutr. 2020 Jul 9:1-8. doi: 10.1080\/10408398.2020.1791049.'><sup>49<\/sup><\/a><\/span>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Addressing_Histamine_Intolerance\"><\/span>Addressing Histamine Intolerance<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Based on the <a href=\"#histamine-balancing\">histamine balancing mechanism<\/a>, unpleasant effects of histamine intolerance may be lessened if amount of histamine circulating in the body is reduced, or if the body improves its ability to metabolize histamine. Our body does not distinguish between endogenous (released by the body) and exogenous (coming with food or released by intestinal bacteria) histamine. So, very often there is a mentioning of a &#8220;bucket&#8221;, that is, a cumulative histamine load in the body. Thus, to deal with the problem and &#8220;empty the bucket&#8221;, one can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduce amount of endogenous and exogenous histamine released and circulating in the blood and digestive system by:\n<ul class=\"wp-block-list\">\n<li>reduction of stress level, sleep hygiene, meditation,<\/li>\n\n\n\n<li>exclusion from the diet foods high in histamine,<\/li>\n\n\n\n<li>supporting &#8220;good&#8221; bacterial in the gut that either do not release histamine, or help to metabolize it,<\/li>\n\n\n\n<li>adoption of hypoallergenic life-style,<\/li>\n\n\n\n<li>taking correct type of anti-histamine medication.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Improve metabolism of histamine already released or consumed and circulating int he body by:\n<ul class=\"wp-block-list\">\n<li>nutritional support of histamine-metabolizing enzymes,<\/li>\n\n\n\n<li>correct type of medication improving histamine metabolism.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image-1.png\"><img loading=\"lazy\" decoding=\"async\" width=\"729\" height=\"473\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image-1.png\" alt=\"\" class=\"wp-image-2239\" style=\"width:591px;height:383px\" srcset=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image-1.png 729w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image-1-300x195.png 300w\" sizes=\"auto, (max-width: 729px) 100vw, 729px\" \/><\/a><\/figure>\n\n\n\n<p>We will consider the rationale of those measures further in this article.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Addressing_Stress_Levels\"><\/span>Addressing Stress Levels<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>As it was mentioned before, stress and anxiety <a href=\"#histamine-sources\">increase histamine release from cells<\/a>. <\/p>\n\n\n\n<p>A study determined how steady-state plasma histamine levels are regulated and affected by environmental factors<span id='easy-footnote-50-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-50-1721' title='Nakamura, Y., Ishimaru, K., Shibata, S. et al. Regulation of plasma histamine levels by the mast cell clock and its modulation by stress. &lt;em&gt;Sci Rep &lt;\/em&gt;7, 39934 (2017). https:\/\/doi.org\/10.1038\/srep39934'><sup>50<\/sup><\/a><\/span>. Since 1960-s, circadian variations of plasma histamine levels, with increase in the early morning hours, were documented. These nocturnal peaks in plasma histamine levels are implicated in the nighttime exacerbation of asthma symptoms. The article concluded that the mast cell &#8220;clock&#8221; mediates circadian release of histamine! The stress negative effect is that it deregulates mast cell &#8220;clock&#8221; leading to spontaneous release of histamine in arbitrary hours. The type of stress my be sub-acute, or interchange of light and ark conditions. <\/p>\n\n\n\n<p>That&#8217;s why we conclude that in order to take control of histamine intolerance, it is important to manage stress levels by focusing on good sleep, breathing and diet.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamine-Friendly_Nutrition\"><\/span>Histamine-Friendly Nutrition<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Currently, international health administrations consider histamine intoxication to be one of the main problems of global food security, due to both for its effects on human health and its impact on trade<span id='easy-footnote-51-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-51-1721' title='FAO (Food and Agriculture Organization of the United Nations); WHO (World Health Organization). Histamine in Salmonids. &lt;em&gt;Joint FAO\/WHO Literature Review; World Health Organization: &lt;\/em&gt;Geneva, Switzerland, 2018; ISBN 9789241514439.'><sup>51<\/sup><\/a><\/span>. The foods with high concentrations of histamine can be a risk to consumers, especially in individuals taking drugs that inhibit DAO or MAO as well as in patients with mastocytosis, tumor, or chronic myelocytic leukemia.<\/p>\n\n\n\n<p>One of the pathways is the ingestion of histamine-rich food, alcohol, or drugs that release histamine. They may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance<span id='easy-footnote-52-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-52-1721' title='Laura Maintz, Natalija Novak, Histamine and histamine intolerance, &lt;em&gt;The American Journal of Clinical Nutrition&lt;\/em&gt;, Volume 85, Issue 5, May 2007, Pages 1185\u20131196, https:\/\/doi.org\/10.1093\/ajcn\/85.5.1185'><sup>52<\/sup><\/a><\/span>. Approximately 1% of the population has histamine intolerance.<\/p>\n\n\n\n<p>Histamine-friendly nutrition is based on 2 principles:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>reduce the amount of histamine coming with foods;<\/li>\n\n\n\n<li>improve the action of histamine-metabolizing enzymes.<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Reducing_Histamine_Load\"><\/span>Reducing Histamine Load<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>In the study<span id='easy-footnote-53-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-53-1721' title='Wagner, N., Dirk, D., Peveling\u2010Oberhag, A., Reese, I., Rady\u2010Pizarro, U., Mitzel, H. and Staubach, P. (2017), A Popular myth \u2013 low\u2010histamine diet improves chronic spontaneous urticaria \u2013 fact or fiction?.&lt;em&gt; J Eur Acad Dermatol Venereol,&lt;\/em&gt; 31: 650-655. https:\/\/doi.org\/10.1111\/jdv.13966'><sup>53<\/sup><\/a><\/span>, a total of 75% of the patients had improvement of histamine-intolerance symptoms from the low\u2010histamine diet. It also was demonstrated that lower-histamine diet improves histamine intolerance symptoms and causes an increase in serum DAO values<span id='easy-footnote-54-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-54-1721' title='Lackner, S., Malcher, V., Enko, D. et al. Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance. Eur J Clin Nutr73, 102\u2013104 (2019). https:\/\/doi.org\/10.1038\/s41430-018-0260-5'><sup>54<\/sup><\/a><\/span>. The website <a href=\"https:\/\/healinghistamine.com\/blog\/\" target=\"_blank\" rel=\"noreferrer noopener\">Healing Histamine<\/a> provides nice and non-restrictive ways to create histamine-friendly nutrition.<\/p>\n\n\n\n<p>So, if histamine intolerance is suspected, the logical way is to reduce dietary histamine load. Always makes sense to check recipes for the histamine content.<\/p>\n\n\n\n<p>Unfortunately, there are no clear guidelines on how much histamine in the food is safe for allergic consumers. Since there is no baseline, we would recommend to check the histamine-friendly food list <a href=\"https:\/\/mastcell360.com\/low-histamine-foods-list\/\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>.<\/p>\n\n\n\n<p>There are sufficient research data estimating the absolute value of dietary histamine content, and effects of the food preparation and storage. Below, we collected some data that can be used to compare other meal options. Foods of animal origin (meat, fish, eggs, dairy) usually contain higher histamine content<span id='easy-footnote-55-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-55-1721' title='Schirone M, Visciano P, Tofalo R, Suzzi G. Histamine Food Poisoning. Handb Exp Pharmacol. 2017;241:217-235. doi: 10.1007\/164_2016_54. PMID: 27752845.'><sup>55<\/sup><\/a><\/span>:<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td><strong>Food<\/strong><\/td><td><strong>Histamine content (mg\/kg) in some food of animal origin <br \/>and wine (mg\/l)<\/strong><\/td><\/tr><tr><td><em>Fish<\/em><\/td><td>&nbsp;<\/td><\/tr><tr><td>Indian mackerel<\/td><td>13.0<\/td><\/tr><tr><td>Fresh anchovies<\/td><td>69.0<\/td><\/tr><tr><td>Fresh sardines<\/td><td>62.0<\/td><\/tr><tr><td>Fresh tuna<\/td><td>478.0<\/td><\/tr><tr><td>Tuna hamburger&nbsp;<\/td><td>304.0<\/td><\/tr><tr><td>Oil-preserved mackerel<\/td><td>&gt;720.0<\/td><\/tr><tr><td>Salted mackerel<\/td><td>68.0<\/td><\/tr><tr><td>Salted tuna<\/td><td>146.0<\/td><\/tr><tr><td><em>Cheese<\/em><\/td><td>&nbsp;<\/td><\/tr><tr><td>Parmigiano Reggiano<\/td><td>38.4<\/td><\/tr><tr><td>Grana Padano<\/td><td>23.9<\/td><\/tr><tr><td>Provolone Valpadana<\/td><td>9.7<\/td><\/tr><tr><td>Pecorino Crotonese<\/td><td>19.1<\/td><\/tr><tr><td>Caciocavallo Silano<\/td><td>42.0<\/td><\/tr><tr><td>Cabrales blue<\/td><td>957.6<\/td><\/tr><tr><td>Gouda<\/td><td>40.0<\/td><\/tr><tr><td>Gorgonzola<\/td><td>255.3<\/td><\/tr><tr><td>Roquefort<\/td><td>376.6<\/td><\/tr><tr><td><em>Fermented sausages<\/em><\/td><td>&nbsp;<\/td><\/tr><tr><td>Catalao<em><\/em><\/td><td>6.1<\/td><\/tr><tr><td>Salsichao<\/td><td>12.5<\/td><\/tr><tr><td>Salami<\/td><td>192.0<\/td><\/tr><tr><td>German types&nbsp;<\/td><td>6.2<\/td><\/tr><tr><td>French types&nbsp;<\/td><td>2.3<\/td><\/tr><tr><td>Italian types&nbsp;<\/td><td>1.4<\/td><\/tr><tr><td><em>Wine<\/em><\/td><td>&nbsp;<\/td><\/tr><tr><td>Red&nbsp;<\/td><td>25.1<\/td><\/tr><tr><td>White&nbsp;<\/td><td>12.5<\/td><\/tr><tr><td>Rose&nbsp;<\/td><td>13.4<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The same source provides data that foods of vegetable origin usually have lower histamine content:<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td><strong>Food<\/strong><\/td><td><strong>Histamine content (mg\/kg) in food of <\/strong><br \/><strong>vegetable origin<\/strong><\/td><\/tr><tr><td>Soy sauce&nbsp;<\/td><td>nd-592<\/td><\/tr><tr><td>Sufu&nbsp;<\/td><td>730.0<\/td><\/tr><tr><td>Miso&nbsp;<\/td><td>nd-221<\/td><\/tr><tr><td>Natto&nbsp;<\/td><td>nd-457.0<\/td><\/tr><tr><td>Soy milk&nbsp;<\/td><td>17.5<\/td><\/tr><tr><td>Tempeh&nbsp;<\/td><td>4.1<\/td><\/tr><tr><td>Tofu&nbsp;<\/td><td>3.5\u20135.8<\/td><\/tr><tr><td>Soybean paste&nbsp;<\/td><td>51.2<\/td><\/tr><tr><td>Tamari&nbsp;<\/td><td>57.65<\/td><\/tr><tr><td>Tomato pasta&nbsp;<\/td><td>2.0\u201310.1<\/td><\/tr><tr><td>Ketchup&nbsp;<\/td><td>2.0\u201318.0<\/td><\/tr><tr><td>Spinach puree<\/td><td>2.1\u20139.8<\/td><\/tr><tr><td>Green pea&nbsp;<\/td><td>2.3\u20133.8<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Food&#8217;s histamine load can be increased by the duration of storage, preparation method, and additives<span id='easy-footnote-56-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-56-1721' title='Durak-Dados, A., Michalski, M., &amp;amp; Osek, J. (2020). Histamine and Other Biogenic Amines in Food.&amp;nbsp;&lt;em&gt;Journal of veterinary research&lt;\/em&gt;,&amp;nbsp;&lt;em&gt;64&lt;\/em&gt;(2), 281\u2013288. https:\/\/doi.org\/10.2478\/jvetres-2020-0029'><sup>56<\/sup><\/a><\/span>. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-7.png\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-7.png\" alt=\"\" class=\"wp-image-1905\" style=\"width:476px;height:318px\" srcset=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-7.png 640w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/01\/image-7-300x200.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/figure>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Improving_Histamine_Metabolism\"><\/span>Improving Histamine Metabolism<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Some research suggests that an adequate intake of healthy fats and other nutrients \u2014 like phosphorus, zinc, magnesium, iron, and vitamin B12 \u2014 may play a role in enhancing DAO activity<span id='easy-footnote-57-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-57-1721' title='Miyoshi M, Ueno M, Matsuo M, Hamada Y, Takahashi M, Yamamoto M, Yamamoto I, Mikajiri R, Tabuchi S, Wakida K, Yamanishi M, Hirai M, Usami M. Effect of dietary fatty acid and micronutrient intake\/energy ratio on serum diamine oxidase activity in healthy women. &lt;em&gt;Nutrition&lt;\/em&gt;. 2017 Jul-Aug;39-40:67-70. doi: 10.1016\/j.nut.2017.03.004.'><sup>57<\/sup><\/a><\/span>. Deficiency in these important nutrients can be assessed virtually using Nutri-IQ<a href=\"https:\/\/www.nutriiq.ca\/nutriIQ.php\" target=\"_blank\" rel=\"noreferrer noopener\"> Nutritional Balance Assessment Tool<\/a>.<\/p>\n\n\n\n<p>DAO production can also be <a href=\"https:\/\/www.healthline.com\/nutrition\/dao-supplement#therapies\" target=\"_blank\" rel=\"noreferrer noopener\">improved nutritionally<\/a>. Enzymatic activity of histidine DAO can last even after bacterial autolysis.<\/p>\n\n\n\n<p>There are common foods that inhibit histamine metabolism. When intolerance is suspected, they may be eliminated from the diet or limited. According to <span id='easy-footnote-58-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-58-1721' title='&lt;a href=&quot;https:\/\/www.medicalnewstoday.com\/articles\/322543&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;Newsletter from Medical News Today.&lt;\/a&gt; Downloaded on January 5, 2020'><sup>58<\/sup><\/a><\/span>, foods that may interfere with DAO and HMNT levels or actions include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>alcohol<\/li>\n\n\n\n<li>energy drinks<\/li>\n\n\n\n<li>green tea<\/li>\n\n\n\n<li>black tea<\/li>\n\n\n\n<li>mate tea<\/li>\n\n\n\n<li>raw egg whites<\/li>\n\n\n\n<li>some yogurt, depending on bacteria type<\/li>\n<\/ul>\n\n\n\n<p>We have seen multiple complaints from the clients when the cleanest diet brought just borderline effect. In those cases, lifestyle changes are a must, and intervention with antihistamines or other medications is required.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"redice-exogenous-histamine\"><span class=\"ez-toc-section\" id=\"Reduction_of_Exogenous_Histamine\"><\/span>Reduction of Exogenous Histamine<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>World Health Organization (WHO) defines probiotics as \u201clive microorganisms which confer a health benefit on the host when administered in adequate amounts\u201d<span id='easy-footnote-59-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-59-1721' title='Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14.'><sup>59<\/sup><\/a><\/span>. Exogenous histamine released by intestinal bacteria (probiotic bacteria) is a very important component of the &#8220;histamine bucket&#8221; and hypersensitivity responses.  <\/p>\n\n\n\n<p>In terms of histamine, probiotic bacteria can be<span id='easy-footnote-60-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-60-1721' title='Which probiotics for histamine intolerance? Downloaded from &lt;a href=&quot;https:\/\/www.optibacprobiotics.com\/professionals\/latest-research\/general-health\/which-probiotic-for-histamine-intolerance&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;Probiotic Professionals&lt;\/a&gt; on Jan. 31, 2021'><sup>60<\/sup><\/a><\/span>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Releasing histamine or suppressing DAO production:\n<ul class=\"wp-block-list\">\n<li>certain gram-negative&nbsp;bacteria&nbsp;such as Escherichia coli and Salmonella typhimurium,<\/li>\n\n\n\n<li>Lactobacillus casei and Lactobacillus bulgaricus (though not all strains within these species will have this effect, but if in doubt then avoid these species to be sure).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Neutral in terms of histamine and\/or DAO production:\n<ul class=\"wp-block-list\">\n<li>Lactobacillus acidophilus NCFM\u00ae, <\/li>\n\n\n\n<li>Bifidobacterium lactis BI-04\u00ae,<\/li>\n\n\n\n<li>B. lactis HN019.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Suppressing histamine and supporting DAO production:\n<ul class=\"wp-block-list\">\n<li>Lactobacillus paracasei CASEI 431\u00ae (not to be confused with Lactobacillus casei as they are completely different species),<\/li>\n\n\n\n<li>Lactobacillus rhamnosus, <\/li>\n\n\n\n<li>Bifidobacterium infantis, <\/li>\n\n\n\n<li>Bifidobacterium longum, <\/li>\n\n\n\n<li>Lactobacillus plantarum, <\/li>\n\n\n\n<li>(possibly) Lactobacillus reuteri,<\/li>\n\n\n\n<li>Lactobacillus plantarum D-1033,<\/li>\n\n\n\n<li>Lactobacillus rhamnosus GG\u00ae.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>The following schematics explaining mechanics of probiotics action was adopted from<span id='easy-footnote-61-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-61-1721' title='Sharma G, Im SH. Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects. &lt;em&gt;Allergy Asthma Immunol &lt;\/em&gt;Res. 2018 Nov;10(6):575-590. https:\/\/doi.org\/10.4168\/aair.2018.10.6.575'><sup>61<\/sup><\/a><\/span>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><a href=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image-e1613081286471.png\"><img decoding=\"async\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2021\/02\/image.png\" alt=\"\" class=\"wp-image-2238\" style=\"width:834px;height:562px\"\/><\/a><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"HI-addressed-medications\"><span class=\"ez-toc-section\" id=\"Addressing_Histamine_Intolerance_with_Medications\"><\/span>Addressing Histamine Intolerance with Medications <span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Anti-histamine medications represent the first line of defence to reduce the severity of histamine intolerance. Antihistamines block the binding of histamine to its receptors or reduce histamine receptor activity<span id='easy-footnote-62-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-62-1721' title='&lt;a href=&quot;https:\/\/en.wikipedia.org\/wiki\/Antihistamine&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;Antihistamine&lt;\/a&gt;. Downloaded on December 23, 2020'><sup>62<\/sup><\/a><\/span>, acting as receptor antagonists.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pharmacological_Antihistamines\"><\/span>Pharmacological Antihistamines <span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Antihistamine medications are selected and prescribed based on physiological function<span id='easy-footnote-63-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-63-1721' title='Antihistamines. Downloaded from &lt;a href=&quot;https:\/\/www.aaaai.org\/conditions-and-treatments\/drug-guide\/allergy-medications&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;American Association of Allergy, Asthma, and Immunology&lt;\/a&gt; on Jan. 4, 2021'><sup>63<\/sup><\/a><\/span>. They affect histamine receptors responsible for the onset of uncomfortable symptoms. Depending on the symptom severity, anti-histamine medications may be either available by prescription only or sold over-the-counter.<\/p>\n\n\n\n<p>Please note that H1 antihistamine medications can cross the blood\u2013brain barrier and cause some detrimental effects on the (CNS), such as hangover-like effects, concentration lapses, lower learning ability<span id='easy-footnote-64-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-64-1721' title='Church M.K. (2016) Allergy, Histamine and Antihistamines. In: Hattori Y., Seifert R. (eds) Histamine and Histamine Receptors in Health and Disease. &lt;em&gt;Handbook of Experimental Pharmacology, &lt;\/em&gt;vol 241. Springer, Cham. https:\/\/doi.org\/10.1007\/164_2016_85'><sup>64<\/sup><\/a><\/span>.<\/p>\n\n\n\n<div class=\"wp-block-columns alignwide are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><tbody><tr><td><strong>Physiological function of histamine receptors<\/strong><\/td><td><strong>Antihistamine<\/strong> <strong>medication<\/strong><\/td><td><\/td><\/tr><tr><td><strong>H1 histamine&nbsp;receptor<\/strong><br \/>\u2022Present in CNS, smooth muscle, heart, immune, epithelial, endothelial, <br \/>adrenal, and sensory nerve cells<br \/>\u2022Mediates&nbsp;post-synaptic&nbsp;effects&nbsp;of&nbsp;histamine&nbsp;in&nbsp;CNS<br \/>\u2022Stimulates smooth muscle contraction in GI and respiratory tract<br \/>\u2022Stimulates&nbsp;sensory&nbsp;nerves&nbsp;causing&nbsp;itching,&nbsp;sneezing, and edema<\/td><td><strong>First generation:<\/strong><br \/>\u2022Chlorpheniramine<br \/>\u2022Clemastine<br \/>\u2022Diphenhydramine<br \/>\u2022Hydroxyzine<\/td><td><strong>Second generation<\/strong><br \/>\u2022Cetirizine<br \/>\u2022Fexofenadine<br \/>\u2022Levocetirizine<br \/>\u2022Loratadine<\/td><\/tr><tr><td><strong>H2 histamine&nbsp;receptor<\/strong><br \/>\u2022Found in gastric mucosa, heart, CNS, immune, airway smooth muscle, <br \/>endothelial, and uterine cells<br \/>\u2022Mediates&nbsp;parietal&nbsp;cells&nbsp;gastric&nbsp;secretion<br \/>\u2022Relaxes&nbsp;smooth&nbsp;muscles&nbsp;and&nbsp;airway vascular system<br \/>\u2022Increases heart rate&nbsp;and&nbsp;contractility<\/td><td>\u2022Cimetidine<br \/>\u2022Famotidine<br \/>\u2022Ranitidine<br \/>\u2022Nizatidine<\/td><td><\/td><\/tr><tr><td><strong>H3<\/strong> <strong>histamine&nbsp;receptor<\/strong><br \/>\u2022Found primarily in CNS<br \/>\u2022Conducts&nbsp;pre-synaptic regulation of neurotransmitters (dopamine, <br \/>norepinephrine), serotonin, acetylcholine, and histamine)<br \/>\u2022Relaxes&nbsp;smooth&nbsp;muscles in&nbsp;airways<\/td><td>\u2022Ciproxifan<br \/>\u2022Pitolisant<\/td><td><\/td><\/tr><tr><td><strong>H4<\/strong> <strong>histamine&nbsp;receptor<\/strong><br \/>\u2022Found in bone marrow, blood, spleen, thymus, lung, GI tract, and CNS<br \/>\u2022Mediates Ca function in mast cells<br \/>\u2022Mediates mast cell migration<\/td><td>\u2022Alcaftadine<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nutraceutical_Antihistamines\"><\/span>Nutraceutical Antihistamines<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Just a small number of herbs had been studied to provide antihistamine effects, and corresponding supplements sold by a Health Food store can assist with root causes and effects of histamine intolerance.<\/p>\n\n\n\n<p>Mast cells can actually be stabilized by several botanicals. A special place belongs to Quercitine as an effective histamine release blocker<span id='easy-footnote-65-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-65-1721' title='Weng, Z., Zhang, B., Asadi, S., Sismanopoulos, N., Butcher, A., Fu, X., Katsarou-Katsari, A., Antoniou, C., &amp;amp; Theoharides, T. C. (2012). Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. &lt;em&gt;PloS one&lt;\/em&gt;, 7(3), e33805. https:\/\/doi.org\/10.1371\/journal.pone.0033805'><sup>65<\/sup><\/a><\/span>. In supplement formulas, it is sometimes mixed with bromelain to reduce inflammation. Also, prickly pear (<em>Opuntia elatior<\/em>) had shown to reduce mast cell degranulation<span id='easy-footnote-66-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-66-1721' title='Chauhan SP, Sheth NR, Suhagia BN (2015) Effect of fruits of Opuntia elatior Mill on mast cell degranulation.&lt;em&gt; J Pharm Bioallied Sci&lt;\/em&gt; 7(2):156\u2013159. https:\/\/doi.org\/10.4103\/0975-7406.148779'><sup>66<\/sup><\/a><\/span>.<\/p>\n\n\n\n<p>For almost 60 years, FDA-approved antihistamine Cromolyn sodium is a golden standard of prevention of mast cell degranulation<span id='easy-footnote-67-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-67-1721' title='Minutello K, Gupta V. Cromolyn Sodium. [Updated 2020 Oct 5]. In: StatPearls [Internet]. Treasure Island (FL): &lt;em&gt;StatPearls Publishing;&lt;\/em&gt; 2020 Jan-.&amp;nbsp;Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557473\/'><sup>67<\/sup><\/a><\/span>. It was initially extracted form plant khella (Ammi visnaga) which had been used as a muscle relaxant since ancient times in Egypt and afterwards was synthesized chemically<span id='easy-footnote-68-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-68-1721' title='&lt;a href=&quot;https:\/\/en.wikipedia.org\/wiki\/Cromoglicic_acid&quot; target=&quot;_blank&quot; rel=&quot;noreferrer noopener&quot;&gt;Wikipedia. Cromoglicic acid&lt;\/a&gt;. Downloaded on Jan 10, 2021'><sup>68<\/sup><\/a><\/span>. Please note that some preparations of Cromolyn Sodium are sold bye prescription only.  <\/p>\n\n\n\n<p>Interesting research is described in <span id='easy-footnote-69-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-69-1721' title='Vadas P, Perelman B. Activated charcoal forms non-IgE binding complexes with peanut proteins. &lt;em&gt;J Allergy Clin Immunol. &lt;\/em&gt;2003 Jul;112(1):175-9. doi: 10.1067\/mai.2003.1480.'><sup>69<\/sup><\/a><\/span> suggested that administration of activated charcoal may be useful to prevent further absorption of peanut protein from the GI tract and avoid excessive release of histamine, after accidental ingestion by individuals with peanut allergy.<\/p>\n\n\n\n<p>Other botanicals with antihistamine properties include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Widely researched is Astragalus membranaceus (also known as Astragalus, Hu\u00e1ng q\u00ed or Milkvetch). It possesses immunoregulatory functions of allergic diseases and can be used as an inflammatory component of allergic asthma treatment<span id='easy-footnote-70-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-70-1721' title='Chao-Bin Shen, Yan-Ni Gu, Song Wang, Lan Yu. Astragaloside IV, the major bioactive component of Astragalus membranaceus (Fisch.) Radix, attenuates airway inflammation by modulating Th2 cytokines, STAT6 and ROR-\u03b3\u03c4 transcription factors in an asthmatic mouse model. The Journal of Immunology May 1, 2019, 202 (1 Supplement) 183.6;'><sup>70<\/sup><\/a><\/span>.<\/li>\n\n\n\n<li>Perilla seeds are a good source of polyunsaturated fatty acids. They suppress the production of chemical mediators in the allergy and inflammatory responses<span id='easy-footnote-71-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-71-1721' title='Asif M. (2011). Health effects of omega-3,6,9 fatty acids: Perilla frutescens is a good example of plant oils. Oriental pharmacy and experimental medicine, 11(1), 51\u201359. https:\/\/doi.org\/10.1007\/s13596-011-0002-x'><sup>71<\/sup><\/a><\/span>.<\/li>\n\n\n\n<li>Java plum or Indian blackberry (also called Jamun or Jambul in Hindi, botanical name Syzygium cumini) effects in-vitro proved to be at par with cromolyn sodium<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nutraceuticals_for_Histamine_Degradation\"><\/span>Nutraceuticals for Histamine Degradation<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Intestinal histamine can undergo <a href=\"#histamine-mentbolosm\">histamine metabolism<\/a> via gastrointestinal degradation. A clinical trial had proven that supplementation with over-the-counter DAO significantly reduces levels of histamine in digestive tract and improves intolerance symptoms<span id='easy-footnote-72-1721' class='easy-footnote-margin-adjust'><\/span><span class='easy-footnote'><a href='https:\/\/www.nutriiq.ca\/wordpress\/histamine-intolerance-and-allergic-reactions-in-mental-disease\/#easy-footnote-bottom-72-1721' title='Schnedl, W.J., Schenk, M., Lackner, S.&amp;nbsp;&lt;em&gt;et al.&lt;\/em&gt;&amp;nbsp;Diamine oxidase supplementation improves symptoms in patients with histamine intolerance.&amp;nbsp;&lt;em&gt;Food Sci Biotechnol&lt;\/em&gt;&lt;strong&gt; 28,&amp;nbsp;&lt;\/strong&gt;1779\u20131784 (2019). https:\/\/doi.org\/10.1007\/s10068-019-00627-3'><sup>72<\/sup><\/a><\/span>. Since the positive research results were obtained fairly recently, there is no wide supply of DAO supplements except, maybe, Histamine Digest from <strong>Seeking Health<\/strong>.<\/p>\n\n\n\n<p>You may want to start by reducing of amount of histamine your body releases.  <strong>Seeking Health<\/strong> provides trusted, made-in-the-USA, and properly tested supplements, including Gut Nutrients blend with Quercetin. In addition, use THE BEST on the market DAO supplement from <strong>Seeking Health<\/strong>, for you to able to eat and drink again! To get these supplements, just click on the images below and use code <strong>IQ10<\/strong> for 10% discount at checkout.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.seekinghealth.com\/products\/gut-nutrients?rfsn=5672253.f31e22&amp;utm_source=refersion&amp;utm_medium=affiliate&amp;utm_campaign=5672253.f31e22\" target=\"_blank\" rel=\"Quercetin noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/GutHealth.jpg\" alt=\"\" class=\"wp-image-4822\" style=\"width:279px;height:auto\" srcset=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/GutHealth.jpg 700w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/GutHealth-300x300.jpg 300w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/GutHealth-150x150.jpg 150w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.seekinghealth.com\/products\/histamine-digest-formerly-histamine-block?rfsn=5672253.f31e22&amp;variant=43682762457267&amp;utm_source=refersion&amp;utm_medium=affiliate&amp;utm_campaign=5672253.f31e22\" target=\"_blank\" rel=\"DAO noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/HistamineDigest.jpg\" alt=\"\" class=\"wp-image-4850\" style=\"width:255px;height:auto\" srcset=\"https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/HistamineDigest.jpg 1000w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/HistamineDigest-300x300.jpg 300w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/HistamineDigest-150x150.jpg 150w, https:\/\/www.nutriiq.ca\/wordpress\/wp-content\/uploads\/2024\/07\/HistamineDigest-768x768.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><\/figure>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>If you think you or your client might have histamine intolerance, conversation with the attending physicians may help to evaluate other possible \u201clook-alike\u201d conditions. Conditions such as true allergies, mastocytosis, or digestive disorders can look similar to histamine intolerance, so they have to be confirmed if possible, and addressed before dealing with histamine intolerance. <\/p>\n\n\n\n<p>At the same time, the <a title=\"https:\/\/www.nutriiq.ca\/histamine.html\" href=\"https:\/\/www.nutriiq.ca\/histamine.html\" target=\"_blank\" rel=\"noreferrer noopener\">Histamine assessment tool offered by Nutri-IQ<\/a> narrows the possibility of histamine intolerance diagnosis and can render significant help to nutritionists and functional medicine practitioners helping clients with histamine intolerance.<\/p>\n\n\n\n<p>When the diagnosis is confirmed, it can be followed by therapy based on a histamine-free and nutrient-rich diet, lifestyle changes, appropriate prescription, and sufficient supplementation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this article, we consider histamine intolerance and allergic reactions in mental disease and gastrointestinal problems, and outline principles of histamine-friendly lifestyle.<\/p>\n","protected":false},"author":1,"featured_media":1747,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_lmt_disableupdate":"no","_lmt_disable":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[31,28],"tags":[169,170,171,168,163,164,165,166,162,160,161,167],"class_list":["post-1721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-info","category-nutrients","tag-anxiety","tag-asd","tag-dao","tag-depression","tag-h1","tag-h2","tag-h3","tag-h4","tag-hi","tag-histamine","tag-histamine-intolerance","tag-mental-disease"],"aioseo_notices":[],"modified_by":"admin","_links":{"self":[{"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/posts\/1721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/comments?post=1721"}],"version-history":[{"count":0,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/posts\/1721\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/media\/1747"}],"wp:attachment":[{"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/media?parent=1721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/categories?post=1721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nutriiq.ca\/wordpress\/wp-json\/wp\/v2\/tags?post=1721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}